Last Week Tonight with John Oliver – S09 E05 : March 27, 2022: Harm Reduction

Last Week Tonight with John Oliver
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John Oliver discusses why overdoses in the U.S. have been on the rise and what we should, and shouldn't, be doing to prevent them. Plus, a rather odd yearly tradition in Nenana, Alaska.

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Cast

Tom Hanks
as Self
Bryan Cranston
as Richard Sackler
Jeff Goldblum
as Detective Zach Nichols
George Clooney
as Self
Helen Mirren
as Self (voice)
BD Wong
as Self
Seth Rogen
as Husband
Edward Norton
as Bridge Inspection Supervisor
J.K. Simmons
as Voice Over (voice)
John Cena
as Self
Steve Buscemi
as Self - Special Guest
Jonathan Banks
as Self
Kathryn Hahn
as Wife
Kiefer Sutherland
as Jack Bauer
Russell Crowe
as Self
Rose Byrne
as Boeing Executive
Michael Keaton
as Richard Sackler
Paul Rudd
as Self
Kristen Bell
as Sarah Marshall
Danny DeVito
as Chemist
Brian Cox
as God
Catherine O'Hara
as Self
Jamie Foxx
as Self (archive footage)
Colin Hanks
as Son
Jake Lacy
as Self
Vincent D'Onofrio
as Dam Inspector
Jennifer Coolidge
as Self
Will Ferrell
as Self
Bobby Cannavale
as Self
David Schwimmer
as Self
Mike Myers
as Self
Patrick Stewart
as Self
Milo Ventimiglia
as Jack Pearson
Keegan-Michael Key
as Responsible Guy
Christopher McDonald
as Company CEO
Peter Jackson
as Self
Cloris Leachman
as Self
Michelle Trachtenberg
as Voice Over (voice)
Jimmy Fallon
as Self
Glenn Close
as Self
Kristin Chenoweth
as Self
Dan Castellaneta
as Homer Simpson (voice)
William Shatner
as Self
Ben Schwartz
as Spokesman
Sarah Silverman
as Self
Nick Kroll
as Cantaloupe (voice) / Coconut (voice)
Nick Offerman
as Self
Aisha Tyler
as Self

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